Methods: An impact of lipopolysaccharide (LPS) and (1→ 3)-β-D-glucan (BG), components of gut bacteria and fungi, respectively, on NETs formation, was explored in lupus models, Fc gamma receptor IIB deficiency (FcGRIIB-/-) and Pristane injection, using Candida-administered dextran sulfate solution induced colitis ( Candida-DSS) model. Introduction: The translocation of organismal molecules from gut into blood circulation might worsen the disease severity of lupus through the induction of neutrophil extracellular traps (NETs). Immunology Unit, Department of Microbiology, Chulalongkorn University, Bangkok, 10330, ThailandĮmail Supichcha Saithong, 1– 3 Wilasinee Saisorn, 3 Peerapat Visitchanakun, 3 Kritsanawan Sae-khow, 3 Direkrit Chiewchengchol, 2, 3 Asada Leelahavanichkul 2, 3ġMedical Microbiology, Interdisciplinary and International Program, Graduate School, Chulalongkorn University, Bangkok, Thailand 2Immunology Unit, Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand 3Translational Research in Inflammation and Immunology Research Unit (TRIRU), Department of Microbiology, Chulalongkorn University, Bangkok, ThailandĬorrespondence: Asada Leelahavanichkul Direkrit Chiewchengchol
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